ESβL and MβL Production in Gram-Negative Bacteria Isolated From HIV Seropositive Individuals
نویسندگان
چکیده
Background: Extended-spectrum β-lactamase (ESβL) or metallo-β-lactamase (MβL) production by gram-negative bacteria in immunocompromised patients poses a serious therapeutic challenge for infection control and is associated with infections higher morbidity/mortality, especially developing countries. This study aimed to phenotypically evaluate the of ESβL as well MβL 75 bacterial isolates from clinical samples human immunodeficiency virus (HIV) positive individuals. Methods: Bacterial identification was chromogenic media, analytical profile index 20 E, NE kits, tested double-disc synergy test (DDST) combination disc method, while screened imipenem ethylene diamine tetra-acetic acid (EDTA) combined EDTA-disc potentiation ceftazidime. Results: Altogether, 57 (76.0%) produced either DDST (6), method (49), both (2). detected enzyme 10.7% which were all Pseudomonas aeruginosa. None revealed imipenem/imipenem-EDTA whereas 26.7% using ceftazidime out 65.0% P. Moreover, ESβL/MβL co-production evident 22.7% aeruginosa constituting 64.7%. Conclusion: among studied indicates heightened resistance β-lactam antibiotics, suggesting grave health consequences, individuals already limiting options region. The compared isolates, predominating producing specie being aeruginosa, detection ceftazidime, respectively.
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ژورنال
عنوان ژورنال: Avicenna Journal of Clinical Microbiology and Infection
سال: 2023
ISSN: ['2383-0301', '2383-0298']
DOI: https://doi.org/10.34172/ajcmi.2023.3394